Hematoporphyrin Is a Promising Sensitizer for Dual-Frequency Sono-photodynamic Therapy in Mice Breast Cancer

Background: The combination of sonodynamic and photodynamic therapy (SPDT) may be a new hopeful non-invasive method for cancer treatment, which incorporates low-intensity ultrasound, laser radiation, sensitizer agent. Objectives: This study aimed at evaluating the effects hematoporphyrin (HP)-mediated SPDT (dual-frequency ultrasound radiation) in management mice breast adenocarcinoma. Methods: One hundred thirty-two female with implanted tumors were divided into 22 groups, including sham, laser, 4 groups dual-frequency ultrasound/laser 8 HP-mediated (2.5 5 mg/kg), HP encapsulated mesoporous silica nanoparticles (HP-MSNs)-mediated SPDT. was administered by intraperitoneal injection after 24-hour delay, tumor grafted treated light. growth factors used to assess treatment outcome. Results: results indicated that or HP-MSNs-mediated had delaying effect. In maximum inhibition (TGI) ratio 47.5%, while TGI 61.6%. time T2 T5 case increased compared sham (P < 0.05). on all 12 days treatment. Analysis experimental data demonstrates this increase not declined persisted over 30 is effective relative volume when group (339.1 ± 161 1510.8 160, respectively). Grade I (low), others III (high) malignancy histological Conclusions: revealed sensitized SPDT, (with without MSNs), has promising effect cancer. Therefore, it can appreciated careful selection will play an eminent role success therapies.